Socio-Economic and Clinical Factors as Predictors of Disease Evolution and Acute Events in COPD Patients

BACKGROUND: Socio-economic, cultural and environmental factors are becoming increasingly important determinants of chronic obstructive pulmonary disease (COPD). We conducted a study to investigate socio-demographic, lifestyle and clinical factors, and to assess their role as predictors of acute events (mortality or hospitalization for respiratory causes) in a group of COPD patients. METHODS: Subjects were recruited among outpatients who were undertaking respiratory function tests at the Pneumology Unit of the Sant'Orsola-Malpighi Hospital, Bologna. Patients were classified according to the GOLD Guidelines. RESULTS: 229 patients with COPD were included in the study, 44 with Mild, 68 Moderate, 52 Severe and 65 Very Severe COPD (GOLD stage). Significant differences among COPD stage, in terms of smoking status and fragility index, were detected. COPD stage significantly affected the values of all clinical tests (spirometry and ABG analysis). Kaplan-Meier estimates showed a significant difference between survival curves by COPD stage with lower event-free probability in very severe COPD stage. Significant risk factors for acute events were: underweight (HR = 4.08; 95% CI 1.01-16.54), having two or more comorbidities (HR = 4.71; 95% CI 2.52-8.83), belonging to moderate (HR = 3.50; 95% CI 1.01-12.18) or very severe COPD stage (HR = 8.23; 95% CI 2.35-28.85). CONCLUSIONS: Our findings indicate that fragility is associated with COPD stage and that comorbidities and the low body mass index are predictors of mortality or hospitalization. Besides spirometric analyses, FeNO measure and comorbidities, body mass index could also be considered in the management and monitoring of COPD patients

new evidence for thermal boundary resistance effects in superconducting 6 ghz cavities

Thermal boundary resistance and, more specifically, Kapitza resistance effects have been often considered as a possible source of "non ideal" superconducting accelerating cavity behavior, through the formation of a temperature difference between the inner cavity superconducting surface and the helium bath. However, in the present literature the general reported assessment is that such effects could be neglected, at least at low or moderate input power. In this communication we present new data on small test bulk Nb 6Ghz cavities, showing that when the cavity surface resistance (or the Q) is plotted as a function of the temperature at constant input power, a clear anomaly occurs at the Helium superfluid transition point Tλ reflecting the abrupt change of the thermal boundary resistance at that temperature. The data analysis shows that this anomaly is consistent with the typically measured values of the thermal boundary (Kapitza) resistance. Implications on the cavity optimization strategy are finally discussed

The low energy spectrum of TeO2 bolometers: results and dark matter perspectives for the CUORE-0 and CUORE experiments

We collected 19.4 days of data from four 750 g TeO2 bolometers, and in three of them we were able to set the energy threshold around 3 keV using a new analysis technique. We found a background rate ranging from 25 cpd/keV/kg at 3 keV to 2 cpd/keV/kg at 25 keV, and a peak at 4.7 keV. The origin of this peak is presently unknown, but its presence is confirmed by a reanalysis of 62.7 kg.days of data from the finished CUORICINO experiment. Finally, we report the expected sensitivities of the CUORE0 (52 bolometers) and CUORE (988 bolometers) experiments to a WIMP annual modulation signal.Comment: 9 pages, 10 figure

Validation of techniques to mitigate copper surface contamination in CUORE

In this article we describe the background challenges for the CUORE experiment posed by surface contamination of inert detector materials such as copper, and present three techniques explored to mitigate these backgrounds. Using data from a dedicated test apparatus constructed to validate and compare these techniques we demonstrate that copper surface contamination levels better than 10E-07 - 10E-08 Bq/cm2 are achieved for 238U and 232Th. If these levels are reproduced in the final CUORE apparatus the projected 90% C.L. upper limit on the number of background counts in the region of interest is 0.02-0.03 counts/keV/kg/y depending on the adopted mitigation technique.Comment: 10 pages, 6 figures, 6 table

Risk of SARS-CoV-2 infection, hospitalization, and death for COVID-19 in people with Parkinson disease or parkinsonism over a 15-month period: A cohort study

Background and purpose: The patterns of long-term risk of SARS-CoV-2 infection, hospitalization for COVID-19, and related death are uncertain in people with Parkinson disease (PD) or parkinsonism (PS). The aim of the study was to quantify these risks compared to a control population cohort, during the period March 2020–May 2021, in Bologna, Northern Italy. Methods: ParkLink Bologna cohort (759 PD, 192 PS) and controls (9226) anonymously matched (ratio = 1:10) for sex, age, district, and comorbidity were included. Data were analysed in the whole period and in the two different pandemic waves (March–May 2020 and October 2020–May 2021). Results: Adjusted hazard ratio of SARS-CoV-2 infection was 1.3 (95% confidence interval [CI] = 1.04–1.7) in PD and 1.9 (95% CI = 1.3–2.8) in PS compared to the controls. The trend was detected in both the pandemic waves. Adjusted hazard ratio of hospitalization for COVID-19 was 1.1 (95% CI = 0.8–1.7) in PD and 1.8 (95% CI = 0.97–3.1) in PS. A higher risk of hospital admission was detected in PS only in the first wave. The 30-day mortality risk after hospitalization was higher (p = 0.048) in PS (58%) than in PD (19%) and controls (26%). Conclusions: Compared with controls, after adjustment for key covariates, people with PD and PS showed a higher risk of SARS-CoV-2 infection throughout the first 15 months of the pandemic. COVID-19 hospitalization risk was increased only in people with PS and only during the first wave. This group of patients was burdened by a very high risk of death after infection and hospitalization

CUORE-0 detector: design, construction and operation

The CUORE experiment will search for neutrinoless double-beta decay of$^{130}$Te with an array of 988 TeO$_2$ bolometers arranged in 19 towers.CUORE-0, the first tower assembled according to the CUORE procedures, was builtand commissioned at Laboratori Nazionali del Gran Sasso, and took data fromMarch 2013 to March 2015. In this paper we describe the design, constructionand operation of the CUORE-0 experiment, with an emphasis on the improvementsmade over a predecessor experiment, Cuoricino. In particular, we demonstratewith CUORE-0 data that the design goals of CUORE are within reach